Polycystic ovary syndrome (PCOS) is a common hormonal disorder that affects many women worldwide. One of the underlying factors associated with PCOS is insulin resistance, a condition in which the body's cells become less responsive to the effects of insulin.
In recent years, a natural compound called myo-inositol has gained attention for its potential role in managing insulin resistance and PCOS symptoms. In this blog post, we will delve into the science behind myo-inositol and its impact on insulin resistance and PCOS.
What is Myo-Inositol?
Myo-inositol is a naturally occurring compound and often referred to as a vitamin-like substance, although it is not technically classified as a vitamin.
It is abundantly found in various foods, such as fruits, grains, and nuts. Within the human body, myo-inositol plays a vital role in cell signalling, insulin regulation, and lipid metabolism.i
Insulin resistance & PCOS
Insulin resistance refers to a condition in which the body's cells do not respond efficiently to insulin, leading to elevated insulin levels in the bloodstream.
In PCOS, insulin resistance is a common characteristic, which can contribute to hormonal imbalances, irregular menstrual cycles, weight gain, and difficulty in conceiving.iv
Insulin resistance can also promote the production of androgens, leading to symptoms like excessive hair growth, acne, and male-pattern baldness.
Myo-Inositol benefits
Research suggests that myo-inositol supplementation may be beneficial in managing insulin resistance and PCOS symptoms. Here are some of the potential ways in which myo-inositol is thought to exerts its effects:
- Improving insulin sensitivity: Myo-inositol may support insulin sensitivity, allowing cells to utilise glucose more efficiently. By improving insulin sensitivity, myo-inositol may help to lower insulin levels, which in turn is thought to reduce the production of androgens and positively impact PCOS symptoms.i
- Regulating hormonal balance: Myo-inositol supplementation has shown promise in supporting hormonal balance in women with PCOS. It may help to normalise luteinising hormone (LH) and follicle-stimulating hormone (FSH) levels, which can lead to improved ovulation and menstrual regularity.iii
- Promoting ovarian function: Myo-inositol has been found to support healthy ovarian function by enhancing the quality of oocytes (eggs) and promoting better follicular development. This can be particularly beneficial for women with PCOS who are trying to conceive.ii
Final thoughts
Myo-inositol shows promising potential in managing insulin resistance and PCOS symptoms. It may help to improve insulin sensitivity, restore hormonal balance, and promote healthy ovarian function.
However, it is important to consult with a healthcare professional before starting any supplementation regimen, as individual needs may vary. Nonetheless, myo-inositol offers hope for women with PCOS, providing a natural approach to support their overall well-being.
References
- i. Nordio M, Proietti E. The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone. Eur Rev Med Pharmacol 2012;16(5):575-581.
- ii. Colazingari S, Treglia M, Najjar R, et al. Myo-inositol decreases insulin resistance and improves reproductive parameters in PCOS patients: a systematic review and meta-analysis of randomized controlled trials. Eur J Obstet Gynecol Reprod 2019;235:8-18.
- iii. Unfer V, Facchinetti F, Orrù B, et al. Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocr Connect. 2017;6(8):647-658.
- iv.Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev. 1997 Dec;18(6):774-800. doi: 10.1210/edrv.18.6.0318. PMID: 9408743.
Meisa
Meisa Nabi graduated from Sheffield Hallam University with BSc (Hons) in Food Science & Nutrition and went on to complete a masters degree in Human Nutrition in 2021 at the University of Sheffield.She is now an Associate Registered Nutritionist (ANutr) with Afn, with a particular interest in gut health and did my masters dissertation on probiotics and their impact on gut health. .
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